Eclipse 2000 Thermogenix Reveiw

Eclipse 2000 Thermogenix is one of the most potent fat burning formulas available over the counter. This formula is specifically designed to burn fat, suppress appetite, enhance metabolic rate, and spare muscle mass. Synephrine and caffeine produce catecholamines that start the fat burning process. White willow, yohimbe, L-tyrosine, cayenne and grapefruit extract all enhance and extend the fat burning or thermogenic effect. Each ingredient has a specific action that enhances the body’s ability to burn fat for fuel.

Thermogenix
Without a doubt the most complete fat burning formula ever developed!

This formula has compiled almost every truly effective compound associated with fatty acid metabolism. The process of burning fat for fuel entails a complex myriad of metabolic functions. 

In order to understand how Thermogenix works, we need to briefly explain this process of lipolysis. The body produces catecholamines that bind to beta 1-2 & 3 receptors. This activates adenyl cyclase, which in turn produces C-Amp and hormone sensitive lipase (HSL). HSL then breaks down stored triglycerides into fatty acids that are released into the blood stream to be used for energy or fuel.(1)

The first generation fat burners utilized ephedrine and caffeine to produce catecholamines.(2) Due to regulatory concerns, the supplement industry is now turning to the 2nd generation fat burner: Synephrine or Citrus Aurantium . 

Synephrine is an adrenergic agonist, which binds to beta 3 and alpha 1 receptors.(3, 4) The beta 3 receptors are responsible for metabolic rate, while alpha 1 may cause constriction of smooth muscle. 

Ephedrine is a nonspecific adrenergic agonist, which binds to beta 1-2 & 3 receptors.(5) Beta 1 & 2 receptors regulate heart rate and blood pressure. 

This is why people experience central nervous system stimulation. Synephrine burns the same amount of fat, spares muscle and suppresses appetite identical to ephedrine but with no stimulant like side effects. 

How Citrus Aurantium Works

Beta 1 receptor Responsible for heart rate actions Beta 2 receptor Responsible for blood pressure Beta 3 receptor Responsible for thermogenisis Ephedra and Citrus Aurantium ignite lipolysis (fat burning) in the same way, by releasing catecholamines to activate beta 3 receptors. Ephedra also activates beta 1 and 2 receptors which raises heart rate and blood pressure. Citrus Aurantium burns fat without the jittery, rush like side effect that ephedra has.

The body has what is called a feedback inhibition mechanism. This is a natural safety defense that tells the body to stop losing weight. 

One action of this mechanism is prostaglandin formation. Prostaglandins can shut down the fat burning process. The white willow bark provides the body with an aspirin analog which can inhibit prostaglandin formation. 

Another feedback inhibition mechanism is the production of phosphodiesterase. This compound blunts the formation of C-amp, which is required for lipolysis. Caffeine has been shown to inhibit phosphodiesterase. 

Yohimbine is an alpha-2-antagonist. This refers to the alpha-receptors, which are primarily found in the lower body and can regulate the amount fat released from these areas. Yohimbine blocks the alpha-2 receptor while synephrine and caffeine turn on the fat burning process thus allowing more fat to be released from these stubborn lower body areas. 

L-tyrosine may enhance synephrine due to the fact that it converts to noradrenaline thus prolonging supplement effectiveness. 

Cayenne powder may have the ability to increase metabolic rate, which adds to the overall breakdown of fatty acids for fuel. 

The final ingredient is grapefruit extract containing naringenin and quercetin. Naringenin is also known for it’s thermogenic effects while quercetin has been found to slow the breakdown of compounds in the liver.(6) This slowing down process may cause the ingredients to stay active longer in the body. 

The best way to take this formula is 2-3 caps 3 times per day about a half an hour before a meal. This dosing pattern may ensure that the synephrine has enough time to enter circulation and increase the caloric expenditure of the meal. 

Overall, this formula has taken into account the various aspects that regulate fatty acid metabolism. 

As expected Eclipse is leading the way with it’s 2nd generation thermogenic formula and plans to continually be at the forefront of physique enhancement.

References
1. Berning, J. R. and Steen N.S. 1991 “Sport Nutrition for the 90’s” Aspen Publishing. Ch 2, p. 15-27.
2. Toubros, et al. 1993. The Acute and Chronic effect of ephedrine/Caffeine mixtures on energy expenditure and Glucose Metabolism in humans. Int J Obes Relate Metab Disord, Dec. 17, suppl.; S73-S77.
3. Germano C. 1998. "Advantra ZTM" - The natural way to lose weight safely. Kensington Publishing. Ch 2, p. 39.
4. Song DK, et al. 1996 “Antidepressant like effect of P-Synephrine in mouse models of immobility tests”. Neurosci Lett. Aug 23; 214 (2-3): p. 107-110.
5. Astrup A. 1995. Pharmacological and clinical studies of ephedrine and other thermogenic agents. Ober Res. Nov. 3 suppl 4: 537S- 540S.
6. Fohr, et al. 1993. British Journal of clinical Pharmacology Apr. 35 (4): p. 431-436.

Thermogenix  Nutritional Facts
Ingredient	Per 3 capsules
L-Tyrosine (as L-Tyrosine  Hydrochloride)	1000 mg
Yohimbe Extract (powered bark) (standardized for 2% Yohimbine)	500 mg
White Willow Bark (powered bark) (standardized for 15% salicin)	500 mg
Citrus Aurantium (standardized for 4% synephrine)	325 mg
Caffeine	150 mg
Cayenne Powder (powdewed	60 mg

Other Thermogenix  Ingredients: Grapefruit Powder Extract, Naringenin and Quercetin.

Recommended Dosage: The best way to take this formula is 2- 3 caps 3 times per day about a half an hour before a meal. This dosing pattern may ensure that the synephrine has enough time to enter circulation and increase the caloric expenditure of the meal. Maximum dose is 3 capsules 3 times daily. Avoid use before bedtime.

Warning:  The recommended dose of this product contains as much caffeine as 1 or 2 cups of coffee. Limit the use of caffeine containing medications, foods or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness and occasional rapid heart beat. As with any drug, if you are pregnant or nursing, seek the advice of a health professional before using this product.